味觉基因对身体脂肪和酒精消费的影响
Mohammad K Shushari1, Tianlan Wei2, Pradtana Tapanee3
1Department of Food Science, Nutrition, and Health Promotion, Mississippi State University, Starkville, MS 39762, USA.
Nutrients
|June 19, 2024
概括
苦味受体基因TAS2R13和TAS2R38的遗传变异在大学生中没有显著影响酒精消费或身体脂肪百分比. 种族,性别和年龄等因素似乎对这些特征更有影响.
科学领域:
- 遗传学 是一个遗传学.
- 营养科学 营养科学
- 生理学 生理学 生理学
背景情况:
- 味觉受体基因的遗传变异可能会影响饮食习惯和酒精消费.
- 苦味受体基因中的多态性,特别是TAS2R13和TAS2R38,正在研究它们对生活方式因素的潜在影响.
研究的目的:
- 为了检查TAS2R13 (rs1015443) 和TAS2R38 (rs1726866,rs10246939,rs713598) 中的多态性和大学生中酒精消费和身体脂肪百分比之间的关系.
主要方法:
- 一组402名大学生提供了关于饮食摄入量 (NIH DHQ II) 和酒精消费 (AUDIT调查) 的数据.
- 苦味受体基因多态性被用TaqMan等位基因歧视试验进行基因定型.
- 对包括种族和性别在内的混变量进行控制的回归模型.
主要成果:
- 在TAS2R13或TAS2R38基因多态化与酒精消费或体脂百分比之间没有发现显著的关联.
- 种族和性别显著影响身体脂肪百分比 (p < 0.001).
- 在控制混杂因子后,TAS2R13 (rs1015443) 和酒精摄入频率之间的初始关联没有持续.
结论:
- 大学生的身体脂肪百分比和酒精消耗可能更多地受到种族,性别和年龄的影响,而不是TAS2R13和TAS2R38基因单核酸多态 (SNP).
- 对口味基因与饮食和身体成分相互作用的进一步研究可能有助于识别人类疾病的风险.
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