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来自Lactobacillus rhamnosus PB01 (DSM 14870) 的后生物质对精子质量的影响:一个前性的体外研究

Sihan Liu¹, Hiva Alipour¹, Vladimir Zachar¹

¹Regenerative Medicine Group, Department of Health Science and Technology, Aalborg University, 9260 Gistrup, Denmark.

|June 19, 2024

概括

乳酸菌后生物可以改善阴道健康,但可能会影响精子质量. 较低剂量对精子是安全的,而较高度会降低运动性,强调在生殖健康应用中需要谨慎剂量.

科学领域:

生殖生物学生殖生物学
微生物组研究微生物组研究
在体外实验室研究.

背景情况:

来自Lactobacillus的阴道后生菌对细菌性阴道炎和怀孕有希望.
这些后生物质对精子质量的影响仍然在很大程度上未被探索.

研究的目的:

实验室内研究乳杆菌后生物对人类精子质量的剂量和时间依赖性影响.
为了确定在生殖环境中使用后生物的安全度范围.

主要方法:

在体外受控研究使用来自18名健康捐赠者的精子样本.
计算机辅助精子分析 (CASA) 评估了运动性,动力学,DNA碎片化和形态学.
精子在0,60分钟和90分钟后以不同的后生物度 (Lactobacillus rhamnosus PB01) 进行化.

主要成果:

低的后生物度 (PB5) 并没有对精子参数产生负面影响.
15%以上的度显著减少了逐渐运动的精子.
在所有时间点中,较高度与非渐进性运动精子呈负相关性.

结论:

后生物剂量对于平衡阴道健康益处与精子质量保护至关重要.
需要进一步的研究来阐明阴道后生菌的机制,并优化阴道后生菌的临床应用.

关键词:

在DNA碎片化过程中,DNA碎片化.乳杆菌 rhamnosusus 的乳杆菌.后生物学的后生物.益生菌是一种益生菌.精子运动性精子运动性

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