代谢功能障碍相关的肥胖性肝病与肝癌之间的关联:当前的概念和未来的挑战
Husam Bader1, Saif Yamin2, Hamzeh Alshahwan2
1Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Journal of clinical medicine
|June 19, 2024
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 显著增加肝癌风险,特别是晚期纤维化. 在MASLD患者中,早期查肝癌至关重要,特别是那些患有并发病的人.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 越来越多地被认为是肝癌的诱导条件.
- 现有的研究表明,MASLD与肝癌发展之间存在联系,需要对全球数据进行进一步的调查.
研究的目的:
- 系统地审查和综合有关MASLD和肝癌发病率之间的联系的最新全球数据.
- 评估肝纤维化阶段和MASLD严重程度作为癌症风险预测者的作用.
主要方法:
- 对评估MASLD与肝癌发病率之间的关系的纵向研究进行系统审查.
- 分析的重点是纤维化得分 (例如,FIB-4),肝细胞癌 (HCC) 发病率和其他肝脏瘤.
- 包括检查MASLD严重程度,并发症和生活方式因素作为风险修饰因素的研究.
主要成果:
- 六项研究表明,MASLD中晚期纤维化是死亡率和肝脏相关事件的独立预测因素.
- 升高的FIB-4得分与HCC和肝硬化风险增加相关; MASLD也与结直肠和乳腺癌有关.
- 鉴定出MASLD的严重程度,糖尿病和吸烟是胆道癌和其他瘤的可修改风险因素.
结论:
- 在MASLD和肝癌风险增加之间存在明显的关联,包括HCC和其他瘤.
- 肝纤维化阶段是MASLD患者癌症风险的关键决定因素.
- 建议对MASLD患者进行肝癌查,特别是那些患有晚期纤维化或其他危险因素的患者.
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