毒药免疫疗法不会影响波兰恶性瘤患者的生存率
Marta Chełmińska1, Krzysztof Specjalski1, Ewa Jassem2
1Department of Allergology, Medical University of Gdańsk, 80-952 Gdańsk, Poland.
Journal of clinical medicine
|June 19, 2024
概括
过敏原免疫疗法 (AIT) 没有增加癌症风险,也没有对昆虫毒过敏患者的存活率产生负面影响. 这项研究发现,与一般人群相比,AIT患者的恶性瘤发生频率较低.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 过敏学 过敏学
背景情况:
- 过敏原免疫疗法 (AIT) 是对诸如鼻炎,喘和昆虫毒液过敏等过敏状况的首要治疗方法.
- 从历史上看,由于担心刺激瘤生长,癌症病史禁忌AIT,尽管缺乏证据.
- 通过AIT调节Th2反应对癌症预后的影响仍然不清楚.
研究的目的:
- 为了确定在接受AIT的患者中恶性瘤的发生率.
- 评估AIT与癌症相关死亡率之间的关联.
- 调查AIT是否影响癌症预后.
主要方法:
- 分析了接受AIT的2577名昆虫毒过敏患者的队列.
- 与波兰国家癌症登记处的数据链接确定了癌症诊断和生存结果.
- 癌症发病率和死亡率与一般人群进行了比较.
主要成果:
- 在3.3%的AIT患者 (86例) 中诊断出恶性瘤,乳腺癌,肺癌和皮肤癌是最常见的.
- 在AIT组的癌症发病率低于一般人群 (159.5比260每10万/年).
- 癌症死亡率在AIT队列中也较低 (37.3对136.8每10万/年),在AIT期间或之后诊断的患者的生存率没有下降.
结论:
- 在接受AIT的患者中,恶性发生的频率低于一般人群.
- AIT似乎不会对癌症预后或生存率产生负面影响.
- 这些发现挑战了在有癌症史的患者中对AIT的传统禁忌.
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