在口服普罗普拉诺洛尔治疗婴儿血管瘤前后进行心脏评估
Ji Hee Kwak1, Aram Yang1, Hye Lim Jung1
1Department of Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, Seoul 03181, Republic of Korea.
Journal of clinical medicine
|June 19, 2024
概括
口服布拉诺醇是一种安全有效的婴儿血瘤 (IHs) 的一线治疗方法. 持续的心脏评估显示,在接受治疗至少六个月的患者中,没有显著的毒性.
科学领域:
- 儿科 儿科 儿科
- 皮肤病学 皮肤病学
- 心脏病学 心脏病学
背景情况:
- 婴儿血管瘤 (IHs) 是婴儿常见的良性血管瘤.
- 口服普罗普拉诺洛尔是IHs推的第一线治疗方法.
- 有限的数据存在于长期心脏作用的普拉诺洛尔在IH患者.
研究的目的:
- 评估口服普罗普兰诺洛尔在患有IHs的婴儿中的心脏安全性和疗效.
- 评估在普拉诺洛尔治疗期间心脏功能和心电图数据的变化.
主要方法:
- 监测了64名被诊断患有IH的婴儿队列,并在两岁之前接受了口服普罗普拉诺洛尔治疗.
- 心脏评估包括心电图,霍尔特监测,胸部X射线和心声回声.
- 在2017年至2021年期间,定期进行后续评估.
主要成果:
- 在64名患者中,没有报告任何严重的心脏不良事件.
- 一年后,用普罗普拉诺洛尔治疗导致血瘤的平均尺寸减少了71.8%.
- 在治疗后的心声图或心电图数据中没有观察到统计学意义上的差异.
结论:
- 口服普罗普兰诺洛尔治疗IH,特别是持续6个月或更长时间的治疗,是安全有效的.
- 在这个婴儿队列中,甲醇没有显示出显著的心脏毒性.
- 持续的心脏监测证实了propranolol在IH管理中的良好的安全性.
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