转移性黑色素瘤的内脉和输液更新
Michelle M Dugan1, Adrienne B Shannon1, Danielle K DePalo1,2
1Department of Cutaneous Oncology, Moffitt Cancer Center, Tampa, FL 33612, USA.
Cancers
|June 19, 2024
概括
本综述研究了晚期黑色素瘤的内伤和输注疗法,包括隔离四肢输注,瘤病毒和免疫检查点抑制剂. 这些治疗方法为管理转移性黑色素瘤提供了新的选择,特定的患者群体从它们的使用中受益.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 免疫治疗是一种免疫疗法.
背景情况:
- 晚期和转移性黑色素瘤带来了重大的临床挑战.
- 黑色素瘤治疗的景观随着新的治疗策略而演变.
- 免疫检查点封锁和向疗法扩大了治疗选择.
研究的目的:
- 审查转移性黑色素瘤的内伤和输液疗法.
- 突出这些治疗方式的演变和当前应用.
- 讨论特定疗法在治疗晚期黑色素瘤中的作用.
主要方法:
- 历史和最近关于内伤口和输注黑色素瘤治疗的文献的综述.
- 讨论治疗方法,包括隔离四肢输液 (ILI),隔离四肢输液 (ILP),瘤病毒和免疫检查点抑制剂.
- 对食品和药物管理局 (FDA) 批准的治疗方法的检查,如塔利摩根拉赫帕雷普韦克 (T-VEC) 和皮肤通肝输液 (PHP).
主要成果:
- 对于晚期黑色素瘤,已经出现了诸如瘤性病毒 (T-VEC) 和输注技术 (ILI,ILP,PHP) 等内部疗法.
- 免疫检查点抑制在晚期黑色素瘤中显示出有效性,并正在探索中转移转移.
- 虽然一些疗法有局限性,但它们对选定的患者群体具有价值.
结论:
- 内溶和输液疗法为管理转移性黑色素瘤提供了有价值的选择.
- 治疗选择需要仔细考虑患者的个人资料,疗效和毒性.
- 继续研究和应用这些疗法对于改善黑色素瘤患者的治疗结果至关重要.
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