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放射治疗对肺癌患者右心室功能的影响

Grzegorz Sławiński¹, Maja Hawryszko¹, Zofia Lasocka-Koriat²

¹Department of Cardiology and Electrotherapy, Faculty of Medicine, Medical University of Gdańsk, 80-210 Gdańsk, Poland.

|June 19, 2024

概括

近一半接受放射治疗的肺癌患者经历了右心室 (RV) 心脏毒性. 心声学,特别是斑点跟踪,有效地检测到早期的RV功能障碍,与3DRV喷射分数不同.

科学领域:

心脏病学心脏病学
在瘤学瘤学.
辐射疗法辐射疗法

背景情况:

抗癌治疗可能会导致心血管方面的副作用.
关于放射治疗 (RT) 对右心室 (RV) 的早期影响的研究有限.
这项研究调查了RT对肺癌患者的RV结构和功能的影响.

研究的目的:

评估RT对肺癌患者RV缩功能的中期影响.
利用现代的心声回声技术来评估RV辐射后的功能.
在检测RV功能障碍时比较不同心声回声测量仪的灵敏度.

主要方法:

一个单一中心的前性研究,比较接受RT加化疗 (研究组) 和单独化疗 (对照组) 的肺癌患者.
包括连续接受肺癌确定的放射治疗的患者.
使用心声回声学,包括TAPSE,RV GLS,RV FWLS和3DRVEF,用于RV功能评估.

主要成果:

在40%的患者中观察到与癌症治疗相关的RV毒性 (CTR-RVT).
在RT后的研究组中,TAPSE和RV全球纵向菌株 (RV GLS) 的早期减少被注意到.
在RT后3个月观察到RV自由壁纵向应变 (RV FWLS) 的显著下降.
在RT后立即对VR的辐射剂量与3D RV射出分数 (3DRVEF) 相对应.
心脏辐射剂量与RT后立即RV FWLS相关.

结论:

RV心脏毒性影响近一半的肺癌患者接受RT治疗.
TAPSE是肺癌治疗期间RV功能下降的敏感标志物.
在检测RT诱导的RV缩功能障碍方面,斑点追踪回声心脏图像优于3DRVEF.

关键词:

三维心声回声学是指三维心声回声学.心脏有毒性心脏有毒性肺癌是一种肺癌.辐射疗法辐射疗法右心室的右心室.斑点跟踪回声心脏图谱斑点跟踪回声心脏图谱

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