未知原始起源的神经内分泌瘤新兴治疗选择:目前的证据和未来的前景
Francesca Corti1, Roberta Elisa Rossi2, Pietro Cafaro1
1Medical Oncology Unit, Fondazione IRCCS San Gerardo dei Tintori, Via G.B. Pergolesi 33, 20900 Monza, Italy.
Cancers
|June 19, 2024
概括
未知原始起源的神经内分泌新生体 (UPO-NENs) 构成了临床挑战. 本综述审查了UPO-NEN的当前和未来治疗方法,重点关注向疗法和分子分析的洞察力.
科学领域:
- 在瘤学瘤学.
- 分子病理学分子病理学
- 翻译医学是一种翻译医学.
背景情况:
- 神经内分泌瘤 (NENs) 包括一个重要的未知原始起源 (UPO-NENs) 的子集,其特点是预后不佳和未满足的临床需求.
- 目前对UPO-NENs的治疗策略缺乏标准化,并依赖于瘤特征,疾病负担和患者状况.
研究的目的:
- 审查过去30年关于UPO-NENs治疗的文献.
- 探索未来的治疗前景,包括向药物和新组合.
主要方法:
- 在过去三十年中发表的关于UPO-NENs治疗的综合文献综述.
- 分析当前的治疗算法和新兴的治疗方式.
主要成果:
- 化疗是高档UPO-NEN的支柱,提供暂时的反应.
- 对分化良好的UPO-NENs的治疗方法各不相同,包括索马托斯塔丁类型,受体放射性体疗法,氨酸激酶抑制剂 (TKIs) 和化疗.
- 分子分析正在揭示具有诊断和治疗潜力的洞察力.
- 预先的数据表明化学免疫疗法,免疫检查点抑制剂 (ICI) 和ICI-TKI组合的活性.
结论:
- UPO-NENs需要根据个体瘤和患者因素量身定制的治疗方法.
- 新兴的向疗法和免疫疗法有望改善UPO-NEN的治疗结果.
- 对分子分析和新型治疗组合的进一步研究对于推进UPO-NEN护理至关重要.
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