药物风险及其与癌症住院患者患者患者报告结果的关联
Maximilian Günther1, Markus Schuler2,3, Leopold Hentschel3
1Department of Clinical Pharmacy, Institute of Pharmacy, University of Bonn, 53121 Bonn, Germany.
Cancers
|June 19, 2024
概括
癌症住院患者经常面临药物风险,多种药物治疗导致与药物相关的问题 (DRPs). 复发状态和住院时间显著影响了与健康相关的生活质量 (HRQOL),而不是药物治疗本身.
科学领域:
- 在瘤学瘤学.
- 临床药房 临床药房
- 医疗保健服务研究 医疗服务研究
背景情况:
- 癌症住院患者面临着重要的药物风险.
- 评估影响健康相关生活质量 (HRQOL) 的因素至关重要.
研究的目的:
- 评估癌症住院患者的药物风险.
- 确定影响住院期间HRQOL变化的因素.
主要方法:
- 药物相关问题 (DRP) 的回顾性分析,使用药物评价和患者报告的结果 (PRO).
- 多种线性回归模型分析了影响HRQOL的社会人口统计学,疾病和药物治疗因素 (EORTC QLQ-C30).
主要成果:
- 分析了162名癌症住院患者;92.6%接受多种药物治疗 (平均11.6种药物),平均为4.0个DRP/患者.
- 专业研究人员确定了21.5%的DRP. 回归模型显示HRQOL的差异较弱至中等.
- 复发状态和住院时间分别对全球HRQOL和身体功能产生了重大影响.
结论:
- 这项研究描述了德国癌症住院患者的DRP.
- 患者报告的结果 (PROs) 增强了药物评价.
- 住院时间和复发状态是影响癌症患者HRQOL的关键因素.
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