作为编程细胞死亡1/编程死亡干1的小分子抑制剂的C2-对称烯基衍生物蛋白与蛋白相互作用

Joanna Klimek1,2, Oskar Kruc1,2, Joanna Ceklarz1

  • 1Department of Organic Chemistry, Faculty of Chemistry, Jagiellonian University, Gronostajowa St. 2, 30-387 Cracow, Poland.

PubMed
概括

针对PD-1/PD-L1免疫检查点的新型小分子化合物为癌症治疗中的抗体药物提供了有希望的替代品. 这些基于的化合物显示出克服当前治疗限制的潜力.

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