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肌肉心脏工作指数预测了患有晚期心力衰竭的患者住院治疗的情况
Giulia Elena Mandoli1,2, Federico Landra1, Benedetta Chiantini1
1Department of Medical Biotechnologies, Division of Cardiology, University of Siena, 53100 Siena, Italy.
Diagnostics (Basel, Switzerland)
|June 19, 2024
概括
心肌工作指数,全球工作指数 (GWI) 和全球建设性工作 (GCW) 在预测晚期心力衰竭患者住院治疗心力衰竭方面表现有前途. 这些心声回声测量可以识别需要更密切监测和治疗调整的个体.
科学领域:
- 心脏病学 心脏病学
- 医疗成像医学成像
- 心脏衰竭研究研究
背景情况:
- 晚期心力衰竭 (AdHF) 存在重大挑战,治疗选择有限.
- 心声学,特别是来自Speckle追踪的心肌工作 (MW),对于诊断和预测心力衰竭非常有价值.
- 评估MW在AdHF的预后分层中的实用性至关重要.
研究的目的:
- 评估心肌工作 (MW) 在晚期心力衰竭 (AdHF) 患者预后分层中的可行性.
- 确定MW指数是否可以预测AdHF的不利结果.
主要方法:
- 对138名AdHF患者 (2018-2022) 的回顾性分析,采用标准心声扫描和左心室 (LV) 应变和MW测量.
- 排除标准包括不良的声学窗户,缺少血压,心房动和明显的回.
- 随访评估综合结果:全因死亡率,LV辅助器件植入,心脏移植和计划外的HF住院治疗.
主要成果:
- 透缩功能,肺压,LV GLS或LV MW指数和重大不良事件之间没有发现关联.
- 全球工作指数 (GWI) 和全球建设性工作 (GCW) 与意外HF住院的风险降低有关 (HR分别为0.90每50mmHg%,p=0.025和p=0.022).
- 卡普兰-梅尔分析表明,LV GWI ≥369 mmHg%的无事件生存率更好.
结论:
- 全球工作指数 (GWI) 和全球建设性工作 (GCW) 证明了对ADHF患者的特征的良好可行性.
- 这些MW指数可以帮助识别患有高风险HF住院和不良事件的AdHF患者.
- 结果表明,GWI和GCW可以指导在ADHF管理中更紧密的后续和治疗决策.
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