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作为表面生物活性涂层的阿伦德罗酸盐:对CaP-阿伦德罗酸盐相互作用的研究

Ines Despotović¹, Željka Petrović², Jozefina Katić³

¹Division of Physical Chemistry, Ruđer Bošković Institute, Bijenička Cesta 54, 10002 Zagreb, Croatia.

Materials (Basel, Switzerland)

|June 19, 2024

概括

植入物上的阿伦德罗酸涂层促进了自发酸沉积,增强了骨质整合. 这种生物材料表面修饰改善了牙植入物的生物活性和骨结合.

科学领域:

生物材料科学生物材料科学
表面化学表面化学
牙科植入物学牙科植入物学

背景情况:

牙植入成功取决于影响组织相互作用和骨融合的表面特性.
促进酸 (CaP) 层形成的生物活性涂层可以增强骨结合和内生长.

研究的目的:

为了研究与alendronate修改的表面上的自发CaP沉积.
为了阐明控制CaP核化和生长在阿伦德罗酸涂层上的机制.

主要方法:

综合实验和理论方法.
量子化学计算 (密度函数理论 - DFT).
使用SEM,EDX,XRD和ATR-FTIR光谱学进行表面表征.

主要成果:

在氧化物表面上发生自发的CaP核化,用负的吉布斯自由能量来表示.
由Ca2+ - 酸盐相互作用和结合驱动的CaP沉积.
实验证实了CaP在阿伦德罗酸涂层的表面上的形成.

结论:

阿伦德罗酸涂层有助于在上自发的生物活性CaP层的形成.
这种表面修饰增强了牙科植入物的生物活性.
结果为开发用于牙科植入物的先进生物材料提供了指导.

关键词:

DFT 的量子化学计算.采用了阿伦德罗酸涂层.生物活性生物活性酸 (CaP) 是一种酸.牙植入物是用制成的牙植入物.

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