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相关概念视频

Immunofluorescence Microscopy01:12

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A fluorescence microscope uses fluorescent chromophores called fluorochromes, which can absorb energy from a light source and then emit this energy as visible light. Fluorochromes include naturally fluorescent substances (such as chlorophylls) and fluorescent stains that are added to the specimen to create contrast. Dyes such as Texas red and FITC are examples of fluorochromes. Other examples include the nucleic acid dyes 4’,6’-diamidino-2-phenylindole (DAPI), and acridine orange.
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Photoluminescence: Applications01:14

Photoluminescence: Applications

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Photoluminescence offers a wide range of applications due to its inherent sensitivity and selectivity. This technique allows for both direct and indirect analyses of the analyte. Direct quantitative analysis is possible when the analyte exhibits a favorable quantum yield for fluorescence or phosphorescence. However, an indirect analysis may be feasible if the analyte is not fluorescent or phosphorescent, or if the quantum yield is unfavorable. Indirect methods include reacting the analyte with...
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相关实验视频

Updated: Jun 23, 2025

Highly Sensitive and Rapid Fluorescence Detection with a Portable FRET Analyzer
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开发一款便携式自流光检测系统及其在生物样本中的应用.

Jiaxing Zhou1, Yunfei Li1, Jinfeng Zhang1

  • 1School of Biomedical Engineering, Hainan University, Sanya 572000, China.

Sensors (Basel, Switzerland)
|June 19, 2024
PubMed
概括

一个新的便携式自光系统可以在皮肤中检测高级糖化最终产品 (AGEs). 这项技术有助于早期诊断慢性疾病,特别是糖尿病 (DM),通过非侵入性监测AGE水平.

科学领域:

  • 生物医学工程 生物医学工程
  • 分析化学 分析化学
  • 医学诊断 医学诊断 医学诊断

背景情况:

  • 先进的糖化最终产品 (AGEs) 是与糖尿病 (DM) 等慢性疾病相关的生物标志物.
  • 现有的AGE检测方法不适合大规模人口查和长期患者监测.
  • 对于早期疾病检测和管理,需要使用非侵入性,便携式诊断工具.

研究的目的:

  • 开发和验证一个便携式的自光检测系统,用于量化皮肤AGE.
  • 评估皮肤AGE水平与已确定的健康指标 (如糖化血红蛋白和血糖) 之间的相关性.
  • 探索AGE与人口统计/生活方式因素之间的关系,用于预测建模.

主要方法:

  • 设计了一种便携式自流光系统,使用395nm激光LED进行激发,并使用光电探测器进行强度测量.
  • 一个520nm光源被纳入皮肤光学属性校准.
  • 该系统的性能在14名志愿者身上得到验证,随着时间的推移,将AGE光与糖化血红蛋白和血糖水平相关联.

主要成果:

  • 在皮肤AGE和糖化血红蛋白之间观察到0.49的相关系数.
  • 长期监测表明,AGE光和血糖水平之间存在强烈的相关性趋势 (>0.95).
关键词:
先进的糖化最终产品 (AGEs)糖尿病管理 糖尿病管理光效应监测 光效应监测一个便携式检测系统.

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  • 多变量分析揭示了AGE与年龄,BMI,性别和体力活动指数之间的相关性.

    • 结论:

    • 开发的便携式自光系统为非侵入性AGE检测提供了一种可行的方法.
    • 皮肤AGE水平与血糖控制相关,可以作为长期血糖监测的指标.
    • AGEs水平受到多种因素的影响,这表明在慢性疾病管理中具有预测建模的潜力.