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Updated: Jun 23, 2025

Detection of Post-Replicative Gaps Accumulation and Repair in Human Cells Using the DNA Fiber Assay
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在前胺A表达细胞中,受损的Fanconi贫血路径有助于复制应激诱导的基因组不稳定性

Pengqing Nie1,2, Cheng Zhang1, Fengyi Wu1

  • 1Department of Gastroenterology, Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Disease, Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Taikang Center for Life and Medical Sciences, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|June 19, 2024
PubMed
概括

通过损害DNA修复通路,先胺A的表达增加了复制压力和基因组不稳定性. 这种功能障碍导致细胞衰老和过早衰老,突出显示了Fanconi贫血路径的作用.

关键词:
芬科尼贫血的途径甲烯基前 A 型复制压力是复制的压力.衰老是一种老化.

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