相关实验视频

Updated: Jun 23, 2025

Analysis of Group IV Viral SSHHPS Using In Vitro and In Silico Methods
10:40

Analysis of Group IV Viral SSHHPS Using In Vitro and In Silico Methods

Published on: December 21, 2019

26.0K

SARS-CoV-2 主要蛋白酶抑制剂利用与酶的溶剂暴露S3位点的独特相互作用

Lauren R Blankenship1, Kai S Yang1, Veerabhadra R Vulupala1

  • 1Texas A&M Drug Discovery Center and Department of Chemistry, College of Arts and Scienes, Texas A&M University, College Station, Texas 77843, United States.

ACS medicinal chemistry letters
|June 19, 2024
PubMed
概括

新型SARS-CoV-2主蛋白酶 (MPro) 抑制剂的设计是针对S3位点,提高COVID-19的治疗潜力. 这些抑制剂通过利用独特的S3位点相互作用来表现出高效率.

更多相关视频

Engineering Antiviral Agents via Surface Plasmon Resonance13:00

Engineering Antiviral Agents via Surface Plasmon Resonance

Published on: June 14, 2022

2.3K
A Fluorogenic Peptide Cleavage Assay to Screen for Proteolytic Activity: Applications for coronavirus spike protein activation07:53

A Fluorogenic Peptide Cleavage Assay to Screen for Proteolytic Activity: Applications for coronavirus spike protein activation

Published on: January 9, 2019

33.2K

相关概念视频

Protein-protein Interfaces02:04

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
12.5K