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领先的识别新型纳弗胺衍生物作为强大的SOS1抑制剂

Dongsheng Li1, Qing Xie1, Maozhi Yang1

  • 1Discovery & Early Development, Haihe Biopharma Co., Ltd., No 865# Zuchongzhi Road Zhangjiang Science City, Shanghai 201203, China.

ACS medicinal chemistry letters
|June 19, 2024
PubMed
概括

研究人员开发了新的SOS1抑制剂,包括化合物HH0043,以向KRAS驱动的癌症. HH0043在临床前模型中显示出显著的瘤抑制,提供了一个有前途的新疗法策略.

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Amines to Sulfonamides: The Hinsberg Test

The Hinsberg test is a method to identify primary, secondary and tertiary amines, named after its pioneer, Oscar Hinsberg. Here, amines are treated with benzenesulfonyl chloride, also known as the Hinsberg reagent, in the presence of an excess of aqueous base, followed by acidification. Based on the nature of the amines, different changes are observed.
Generally, a primary amine reacts with the Hinsberg reagent to produce an N-substituted benzenesulfonamide. The electron-withdrawing...
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