慢性阻塞性肺病患者的维生素D状态和身体组成的纵向变化 - 一项前性观察性研究
Maria Minter1,2, Jenny van Odijk1, Hanna Augustin1
1Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, 405 30, Sweden.
概括
慢性阻塞性肺病 (COPD) 患者的维生素D水平较低,但不会随着时间的推移影响身体组成的变化. 维生素D不足和低骨矿物质密度在COPD患者中更常见.
科学领域:
- 肺部医学 肺部医学
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 在慢性阻塞性肺病 (COPD) 中,体重和身体组成的变化很普遍,影响了发病率和死亡率.
- 低维生素D状态在COPD患者中很常见,与肺功能减弱和肌肉缩有关.
- 这项研究研究了COPD患者的维生素D水平和身体组成之间的关系.
研究的目的:
- 为了评估维生素D水平和状态与COPD患者的身体组成 (BC) 之间的关联.
- 评估维生素D如何影响随着时间的推移改变身体成分.
- 为了比较COPD患者和对照者的维生素D状态和身体成分.
主要方法:
- 包括COPD患者和对照组在内的前性观察研究 (ICE-Age).
- 在基线测量血25-氧维生素D (25(OH) D.
- 在基线和两年后,通过双能X射线吸收计评估的身体组成 (BC).
主要成果:
- 慢性肺炎患者的维生素D水平明显低于对照组 (64 ± 26 nmol/L vs. 75 ± 25 nmol/L).
- 这两组在两年内都显示出无脂肪质量指数 (FFMI) 和部T-score的下降.
- 维生素D水平或状态与两组人体组成或其变化无关.
结论:
- 维生素D状况与身体组成或身体组成的纵向变化无关.
- 与对照组相比,COPD患者的维生素D缺乏和骨矿物质密度 (BMD) 低的情况更为普遍.
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