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周围假肢关节感染研究中的性别相关差异

Domenico De Mauro^1,2,3, Cesare Meschini^1,2, Giovanni Balato³

¹Department of Orthopedics and Rheumatological Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Journal of bone and joint infection

|June 19, 2024

概括

与女性相比,男性在全关节整形术 (TJA) 后患上周围假肢关节感染 (PJI) 的风险更高. 进一步的与性别相关的分析对于理解骨科结果中的这些差异至关重要.

科学领域:

整形外科手术整形外科手术
传染性疾病传染性疾病
医学研究医学研究

背景情况:

周围假肢关节感染 (PJIs) 是全面关节整形术 (TJA) 后的一个重要并发症.
增加的发病率和对患者的影响需要对风险因素有更深入的了解.
现有的研究趋势分析风险因素,并发症和治疗方法,但与性别相关的差异需要进一步阐明.

研究的目的:

系统地审查和分析有关周围假肢关节感染 (PJI) 性别相关差异的现有文献.
为了确定进行全关节整形手术 (TJA) 的男性和女性患者之间PJI风险的潜在差异.
突出需要加强对骨科感染结果的性别特定研究.

主要方法:

按照系统审查和元分析 (PRISMA) 准则的优先报告项目进行的系统审查.
包括纵向研究 (追溯和前性) 和随机对照试验.
进行了基于性别的分析,以比较男性和女性之间的感染率和风险.

主要成果:

从312个来源的初步搜索中,包括了9项研究.
八项研究调查了TJA后PJI的风险.
大约一半的研究发现,与女性相比,男性的感染并发症风险在统计上显著地更高.

结论:

目前的文献表明,男性可能比女性更容易患TJA后的PJIs.
进一步调查与性别相关的因素对于改善PJI预防和管理策略至关重要.
强大的,性别特定的数据对于推进骨科研究和患者护理至关重要.

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