评估重症监护室中药物诱导的电解质障碍:一个多中心观察性研究
Yunus Emre Ayhan1, Enes Emir İlerler2, Damla Sosyal3
1Department of Clinical Pharmacy, Prof. Dr. Cemil Taşcıoğlu City Hospital, Istanbul, Türkiye.
Frontiers in medicine
|June 19, 2024
概括
电解质障碍 (ED) 在重症监护室 (ICU) 很常见,影响75.2%的患者. 这些疾病与增加的死亡率和机械通风有关,药物参与是一个重大问题.
科学领域:
- 临界护理医学 临界护理医学
- 临床化学 临床化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 电解质障碍 (ED) 经常在被送往重症监护室 (ICU) 的重症患者中观察到.
- 了解ED的患病率和促成因素对于改善患者的治疗结果至关重要.
研究的目的:
- 为了确定ICU患者中ED的频率.
- 评估EDS与该人群中药物使用之间的关系.
主要方法:
- 一项涉及医疗和麻醉学ICU的前性多中心研究.
- 在ICU入院或住院期间包括至少一个ED患者.
- 使用物流概率方法尺度 (LPMS) 和专家小组评估评估ED药物关系的评估.
- 统计分析包括肯达尔相关性,二进制逻辑回归和在p < 0.05时设置的显著性.
主要成果:
- 总共研究了117名患者,其中88名 (75.2%) 患有至少一种ED.
- 在LPMS中,发现39.6%的ED是与药物相关的,而专家小组的这一比例为21.7% (p < 0.001).
- 患有ED的患者的死亡率 (50%vs13.7%) 和机械通风率 (52.2%vs17.2%) 显著增加 (p < 0.001).
- ED与死亡率增加 (OR:8.352) 和机械通风 (OR:3.229) 相关.
- 肠道或亲肠道养与ED更高的可能性有关 (分别为OR:30.057和OR:5.537).
结论:
- 电解质障碍在重症监护室非常普遍,缺血是常见的.
- EDs与增加机械通风,长时间住院和更高的死亡率有关.
- 该研究质疑LPMS是否适合在ICU环境中评估ED药物关系.
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