相关实验视频

Updated: Jun 23, 2025

Investigating Alterations in Caecum Microbiota After Traumatic Brain Injury in Mice

Investigating Alterations in Caecum Microbiota After Traumatic Brain Injury in Mice

Published on: September 19, 2019

饮食与微生物组的相互作用促进了脊髓损伤后肠道神经系统的弹性

Adam M Hamilton¹, Lisa Blackmer-Raynolds¹, Yaqing Li¹

¹Department of Cell Biology, Emory University School of Medicine, Atlanta GA 30329.

bioRxiv : the preprint server for biology

|June 19, 2024

概括

食胰岛素通过调节肠道微生物及其代谢物来预防脊髓损伤 (SCI) 后的肠道神经系统缩和肠道动力障碍. 这突出了神经性肠道治疗的饮食-微生物群-免疫轴.

科学领域:

神经科学是一个神经科学.
胃肠病学胃肠病学
免疫学免疫学免疫学

背景情况:

脊髓损伤 (SCI) 导致广泛的生理功能障碍,包括肠道动力障碍和肠道神经系统 (ENS) 缩.
尽管ENS具有典型的弹性,但SCI后持续性肠道问题的确切原因仍然不清楚.
新兴的研究将SCI与肠道微生物组的改变联系在一起,这表明SCI在ENS恢复中可能发挥作用.

研究的目的:

调查调节肠道微生物组是否可以促进SCI后的ENS恢复.
确定食纤维 (胰岛素) 和微生物代谢物对肠道功能和SCI后ENS完整性的影响.

主要方法:

患有SCI的小鼠被用胰岛素,SCI相关的微生物组或微生物短链脂肪酸 (SCFA) 治疗.
评估了对ENS缩,肠道不运动以及IL-10信号传递的作用的影响.

主要成果:

在SCI小鼠中,注射胰岛素预防了ENS缩,并减少了肠道动力障碍.
仅仅微生物干预并没有完全恢复肠道功能.
微生物衍生的SCFA模仿了胰岛素对ENS的保护作用.
胰岛素的保护作用取决于细胞因子IL-10的信号传递.

结论:

饮食干预措施,特别是胰岛素,可以保护ENS,并改善SCI后的肠功能.
微生物代谢物 (SCFA) 在这种保护作用中起着至关重要的作用.
涉及IL-10的饮食-微生物群-免疫轴对SCI后的ENS弹性至关重要.
这个轴为SCI诱导的神经性肠道提供了潜在的治疗点.

更多相关视频

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice

Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice

Published on: June 2, 2022

相关概念视频

Enteric Nervous System: Regulation of GI Motor Activity

Enteric Nervous System: Regulation of GI Motor Activity

The Enteric Nervous System (ENS) plays a pivotal role in regulating gastrointestinal or GI motor activity. This complex network of nerves, deeply embedded within the gut wall, responds to changes in the gut environment and receives input from both the autonomic nervous system and the central nervous system. By doing so, the ENS operates various programs tailored to the body's nutritional status and needs.
During periods of fasting, the ENS initiates the migrating myoelectric complex, a...

Physiology of Enteric Nervous System and Gut Health

Physiology of Enteric Nervous System and Gut Health

The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...

Neurogenesis and Regeneration of Nervous Tissue

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...