解开阿尔茨海默病:通过DCC-GARCH建模研究默认模式网络中的动态功能连接
Kun Yue1, Jason Webster2, Thomas Grabowski2,3
1Department of Biostatistics, University of Washington, Seattle.
bioRxiv : the preprint server for biology
|June 19, 2024
概括
这项研究引入了使用DCC-GARCH模型用于敏感阿尔茨海默病 (AD) 检测的动态大脑功能连接分析. 它对早期粉样蛋白β (Aβ) 生物标志物识别有希望,克服了当前方法的局限性.
科学领域:
- 神经科学是一个神经科学.
- 生物标志物发现发现
- 医疗成像医学成像
背景情况:
- 阿尔茨海默病 (AD) 具有很长的临床前阶段,需要早期检测生物标志物.
- 目前的粉样蛋白β (Aβ) 生物标志物 (CSF,PET,血) 有成本,可用性或生理相关性等局限性.
- 大脑功能连接 (FC) 的改变与AD病理有关,提供了潜在的非侵入性检测途径.
研究的目的:
- 探索动态功能连接 (FC) 使用静止状态功能MRI (rs-fMRI) 在阿尔茨海默病中进行非侵入性Aβ检测.
- 引入和评估用于分析动态FC的通用自回归条件异种类动态条件相关性 (DCC-GARCH) 模型.
主要方法:
- 使用了休息状态功能性MRI (rs-fMRI) 数据.
- 应用了新的通用自回归条件异种类动态条件相关性 (DCC-GARCH) 模型来分析动态的大脑功能连接.
- 与DCC-GARCH模型对脑脊液 (CSF) Aβ状态的敏感性进行比较.
主要成果:
- 与传统方法相比,DCC-GARCH模型在检测Aβ状态方面表现出更高的灵敏度.
- 使用DCC-GARCH的动态FC分析为AD相关的大脑网络变化提供了重要的见解.
- 这种方法显示了在AD检测中单个受试者级别灵敏度的潜力.
结论:
- 动态FC分析,特别是使用DCC-GARCH模型,为早期发现阿尔茨海默病提供了一个有前途的非侵入性方法.
- 这种方法有可能通过通过大脑连接模式检测Aβ病理来识别有风险的个体.
- 对动态FC的进一步研究可以完善早期AD诊断和风险评估.
更多相关视频
08:43Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
Published on: August 7, 2017
7.9K
09:47Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches
Published on: December 15, 2023
1.0K
相关概念视频
Alzheimer's Disease: Overview
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Alzheimer Disease l: Introduction
Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
Alzheimer Disease ll: Pathophysiology
Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...
Dementia l: Introduction
Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
