贝塔-上腺体信号传递和T-淋巴细胞产生的甲醇胺对于17A介质素的合成是必要的
Tatlock H Lauten1,2, Safwan K Elkhatib3, Tamara Natour1,2
1Department of Psychiatry and Behavioral Sciences, Texas A&M University, Bryan, TX, United States.
bioRxiv : the preprint server for biology
|June 19, 2024
概括
通过β-上腺素受体传递交感信号直接影响T淋巴细胞IL-17A的产生. 阻断这些受体和甲基荷兰胺会减少促炎性细胞因子的产生,为PTSD和自身免疫性疾病提供新的治疗点.
科学领域:
- 神经免疫学 神经免疫学
- 心理神经免疫学 心理神经免疫学
- T细胞免疫学T细胞免疫学
背景情况:
- 创伤后应激障碍 (PTSD) 与神经免疫系统的不规则性和自身免疫性疾病的风险增加有关.
- 创伤后应激障碍患者的同情度升高表明神经系统在免疫失调中的作用.
- 之前的研究表明,同情信号影响T淋巴细胞的炎症性细胞因子产生,但机制尚不清楚.
研究的目的:
- 在临床前PTSD模型中阐明将同情信号与T淋巴细胞IL-17A产生联系的机制.
- 为了研究上腺素受体和甲醇胺在T淋巴细胞IL-17A生成中的作用.
- 探索T淋巴细胞产生的甲醇胺对免疫反应的影响.
主要方法:
- 在男性和女性受试者中使用了经过修改的重复社会失败压力 (RSDS) 模型.
- 评估了上腺素受体阻塞 (遗传和药理学) 和甲基荷胺耗尽的影响.
- 检查了在CD4+和CD8+T淋巴细胞中对IL-17A的产生,这些T淋巴细胞被极化出体.
主要成果:
- 在RSDS后,对β 1和2上腺素受体 (β1/2) 的药理学阻塞显著降低了循环IL-17A水平.
- 基因淘汰β1/2受体和转移β1/2淘汰T淋巴细胞证实了这些发现.
- 在B1/2阻塞后,T淋巴细胞显示IL-17A的产量减少,即使没有外部类甲醇胺,也表明自身隐性信号传递.
- 在体内和体外缩的T-淋巴细胞IL-17A生产中,catecholamines的耗尽.
结论:
- 鉴定了β1/2上腺素受体和T-淋巴细胞IL-17A生产中自身类甲醇胺信号传递的新型作用.
- 这些发现突出了免疫生成的神经传递的新途径,影响了亲炎性细胞因子的产生.
- 这项研究表明,对于涉及IL-17A病理的精神病和自身免疫性疾病来说,它是一个潜在的治疗标.
相关概念视频
T Cell Types and Functions
999
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
999
T Cell Activation and Clonal Selection
701
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
701
B Cell Activation and Differentiation
1.7K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.7K
Adrenergic Receptors: β Subtype
1.6K
β-adrenoceptors have varied sensitivities towards adrenaline, noradrenaline, and isoprenaline. The order of agonist potency is as follows:
Isoprenaline > Adrenaline > Noradrenaline
Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
β1-adrenoceptors: β1-adrenoceptors...
Isoprenaline > Adrenaline > Noradrenaline
Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
β1-adrenoceptors: β1-adrenoceptors...
1.6K
The JAK-STAT Signaling Pathway
8.8K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
8.8K
Cells of the Adaptive Immune Response
979
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
979


