IL-7和IL-15之间的协作使组织居民和循环记忆CD8+ T细胞的适应成为可能
Nicholas N Jarjour1,2, Talia S Dalzell1,2, Nicholas J Maurice1,2
1Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
bioRxiv : the preprint server for biology
|June 19, 2024
概括
互白素-7 (IL-7) 和IL-15细胞因子共同工作,维持记忆CD8+ T细胞,包括组织内存 (TRM) 细胞. 它们的联合作用确保了T细胞弹性,当任何一种细胞因子的可用性较低时.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- T细胞生物学T细胞生物学
背景情况:
- 互白素-7 (IL-7) 被认为对记忆CD8+T细胞恒温至关重要.
- 以前的研究集中在循环T细胞上,而不是组织内存 (TRM) 细胞.
- 在记忆T细胞维护中IL-7信号传递的细胞内在作用尚不清楚.
研究的目的:
- 调查IL-7Rα信号传递在记忆CD8+T细胞平衡中的作用,包括TRM子集.
- 为了确定细胞内在的IL-7信号传递在记忆T细胞持久性的要求.
- 探索IL-7和IL-15在记忆CD8+T细胞维护中的信号传递之间的相互作用.
主要方法:
- 在CD8+ T细胞中诱导IL-7受体α链 (Il7ra) 的缺失.
- 对循环和组织内存 (TRM) CD8+ T细胞种群的分析.
- 在不同的IL-7和IL-15信号条件下评估T细胞增殖和存活率.
主要成果:
- 失去Il7ra对记忆CD8+T细胞的持久性产生了适度的影响,但对基底增殖至关重要.
- 当IL-7Rα信号缺乏IL-15信号时,IL-7Rα信号对内存CD8+T细胞,包括TRM,变得更加关键.
- 缺少IL-15导致IL-7Rα表达的增加和对IL-15的反应中的增殖受损,表明交叉调节.
结论:
- IL-7和IL-15信号作用协同,以支持不同亚组和组织的记忆CD8+T细胞平衡.
- 由于这种协调的信号传递,记忆CD8+ T细胞对单个细胞因子可用性的变化具有弹性.
- IL-7Rα在调节记忆CD8+T细胞的增殖中起着关键作用,特别是在IL-15缺乏的情况下.
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