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Updated: Apr 28, 2026

Protocol for Recombinant RBD-based SARS Vaccines: Protein Preparation, Animal Vaccination and Neutralization Detection
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设计一种针对RBD隐秘面部的SARS-CoV-2疫苗,通过免疫聚焦准RBD隐秘面部

Theodora U J Bruun1,2, Jonathan Do1,2, Payton A-B Weidenbacher1,3

  • 1Sarafan ChEM-H, Stanford University, Stanford, CA 94305.

bioRxiv : the preprint server for biology
|June 19, 2024
PubMed
概括

使用PMD-RBD免疫原的新疫苗策略成功集中了抗体反应,以准SARS-CoV-2尖端蛋白的神秘面部. 这种方法增强了对Sarbecoviruses的广泛中和,这对未来的疫苗开发至关重要.

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Vaccine Production01:23

Vaccine Production

Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...
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