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Updated: Jun 23, 2025

Sensitive Detection of Proteopathic Seeding Activity with FRET Flow Cytometry
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Published on: December 8, 2015

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由FUS的种子聚集和传播引起的前性痴呆症样疾病进展

Sonia Vazquez-Sanchez, Britt Tilkin, Fatima Gasset-Rosa

    bioRxiv : the preprint server for biology
    |June 19, 2024
    PubMed
    概括

    人类FUS纤维素可以在小鼠大脑中播种FUS蛋白的聚合和传播,模仿神经退行性疾病. 这种类似子的传播,由ALS相关的FUS突变加速,导致FUS蛋白质病变和FTLD类症状.

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