任务对功能性大脑连接性的影响,来源于个人间的相关性:从功能性MRI数据的区域同质性获取的洞察力
Xin Di1, Pratik Jain1, Bharat B Biswal1
1Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, 07102, USA.
bioRxiv : the preprint server for biology
|June 19, 2024
概括
大脑的功能连接在各个任务中是非常一致的,与特定的大脑区域相关的微妙差异. 这种一致性表明,任务设计对于未来的个人间大脑连接研究至关重要.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 脑部成像 脑部成像
背景情况:
- 功能连接性研究经常使用fMRI和PET的个体内相关性.
- 许多研究使用静止状态条件,引发了有关任务特异性对个人间相关性影响的问题.
研究的目的:
- 调查不同任务条件如何影响个人间功能连接的估计.
- 确定大脑功能连接模式在各种任务中的一致性.
主要方法:
- 分析了100名参与者在七项任务和休息状态中的fMRI数据.
- 计算区域同质性 (ReHo) 作为脑功能的区域测量.
- 评估了个人间的相关性模式及其在各个任务中的一致性.
主要成果:
- 与跨区域变化相比,ReHo的任务诱导变化很小.
- 全大脑个体间的相关性模式在各个任务中显示出很高的一致性 (r > 0.78).
- 连接性变化主要观察到视觉,体力运动和默认模式网络.
结论:
- 个人间的功能连接在不同任务中基本上是一致的.
- 与任务相关的微妙的连接差异可能是特定于区域的.
- 未来的研究应该考虑任务设计在研究特定的大脑系统.
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