个性化干预以改善多发性硬化症患者的药物坚持
Efrat Neter1, Efrat Esterkin-Hubner2, Lea Glass-Marmor2
1Ruppin Academic Center, Emeq Hefer, Israel.
Patient preference and adherence
|June 19, 2024
概括
这项研究发现,综合心理教育和动机面试 (MI) 干预最初改善了复发性复发性多发性硬化症 (PwRRMS) 患者的药物坚持. 然而,这些收益并没有持续长期,这表明需要持续支持.
科学领域:
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
- 公共卫生 公共卫生
背景情况:
- 复发性复发性多发性硬化症 (RRMS) 需要一致的疾病修饰治疗 (DMT) 坚持最佳管理.
- 在RRMS中不遵守DMT可以导致疾病进展和增加医疗保健成本.
- 心理教育和动机面试 (MI) 是改善药物坚持的潜在策略.
研究的目的:
- 评估面对面心理教育和MI干预的可接受性,保留性和有效性,以改善RRMS (PwRRMS) 患者的DMT坚持.
- 评估干预对12个月内自我报告的药物坚持的影响.
主要方法:
- 使用了准实验性的测试前测试后测试设计,其中60个PwRRMS被确定不符合他们的DMT.
- 参与者接受了医生咨询,量身定制的MI会议,电话提升器和后续MI会议的组合.
- 患者报告的结果,包括坚持得分,在基线,6个月和12个月收集.
主要成果:
- 保持率合理,60名参与者中有52人完成了干预,46人完成了12个月的随访.
- 与基线相比,6个月后的坚持得分显著改善 (p = 0.030).
- 然而,12个月的坚持得分与基线没有显著差异 (p = 0.106),表明缺乏持续效果.
结论:
- 综合精神教育和MI协议在提高PwRRMS的药物坚持方面表现出初始的有效性.
- 这项研究强调了需要持续或更频繁的干预措施,以保持长期的坚持改善.
- 进一步的研究应该探索慢性疾病管理中长期坚持支持的战略.
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