在544名门诊患者中,功能,海马体积和认知障碍之间的关联
Lei-Yun Wu1, Yuan-Yuan Lu2, Shuang-Shuang Zheng3,4
1Department of Nephrology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Frontiers in neurology
|June 19, 2024
概括
较高的估计膜过率 (eGFR) 与较大的海马体积 (HCV) 和更好的认知相关. 即使轻微减少的EGFR也可能导致海马缩,这是认知障碍的危险因素.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 神经学 神经学
- 放射学 放射学是指放射学
背景情况:
- 认知障碍和脑缩在慢性病 (CKD) 患者中很普遍.
- 功能变化的影响,即使在正常范围内,对海马体积 (HCV) 和认知还没有完全理解.
- 这项研究研究了估计的淋巴细胞过率 (eGFR),HCV和非CKD门诊患者的认知功能之间的关系.
研究的目的:
- 检查eGFR,HCV和门诊患者的认知表现之间的关联.
- 为了确定海马缩和认知障碍的危险因素.
- 为了确定HCV对认知衰退的预测值.
主要方法:
- 544名非脏门诊患者的回顾性分析.
- 通过3.0TMRI评估功能 (eGFR),海马体体积 (HCV) 和认知功能 (MMSE,MoCA).
- 使用了相关性,逻辑回归和ROC曲线分析.
主要成果:
- 在eGFR,HCV和认知得分 (MMSE,MoCA) 之间观察到正相关性.
- 较低的eGFR (<75mL/min/1.73m2),年龄较大,葡萄糖水平较高以及大脑微血管疾病是海马缩的危险因素.
- 左海马体积 (LHCV) < 2,654 mm3 被确定为认知障碍的独立风险因素,显示出比年龄更高的预测值.
结论:
- 更高的eGFR与更大的HCV和更好的认知功能有关.
- 降低eGFR,即使在正常范围内,也可能与海马缩以及随后的认知障碍有关.
- LHCV作为一个重要的预后标记,用于预测门诊患者的认知障碍.
更多相关视频
06:23The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease
Published on: October 13, 2016
32.3K
12:50Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly
Published on: April 14, 2014
40.2K
相关概念视频
Role of Hippocampus in Memory
218
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
218
Factors Affecting Renal Clearance: Renal Impairment
81
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
81
