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肠道微生物群和基底细胞癌之间的遗传因果关系:一项两样本的门德尔随机化研究

Pan Luo¹, Dejin Gao¹, Qingguo Zhang¹

¹Department of Comprehensive Plastic Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)

|June 19, 2024

概括

这项研究研究了肠道微生物群.

科学领域:

微生物组研究的研究.
癌症基因组学癌症基因组学
遗传流行病学遗传流行病学

背景情况:

肠道微生物组 (GM) 与各种癌症有关,但其在基底细胞癌 (BCC) 中的因果作用仍未得到充分探索.
现有的研究还没有使用孟德尔随机化 (MR) 来评估肠道微生物群对BCC发育的影响.

研究的目的:

使用MR来调查特定肠道细菌和BCC之间的潜在因果关系.
分析四个关键肠道微生物群体 (细菌菌,链球菌,蛋白菌,拉克诺斯皮拉菌) 与BCC的发病率之间的关联.

主要方法:

利用全基因组关联研究 (GWAS) 数据和孟德尔随机化 (MR) 分析.
采用逆方差加权 (IVW) 模型,并补充了简单模式,加权中位数,加权模式和MR-Egger方法.
通过异质性和水平变性测试评估分析可靠性;MR-PRESSO用于异常值的检测和纠正.

主要成果:

在Bacteroides,Streptococcus,Proteobacteria或Lachnospiraceae和基底细胞癌 (BCC) 之间没有发现显著的遗传因果关系.
所有测试的微生物群体在MR分析中都没有证据表明横向质,异质或异常值.
具体结果:细菌类 (OR=0.936,p=0.455),链球菌 (OR=0.974,p=0.629),蛋白质细菌 (OR=1.113,p=0.106),拉克诺斯皮拉属 (OR=1.027,p=0.688).这些细菌中,有三种类型的细菌.

结论:

该研究得出的结论是,研究的肠道细菌 (细菌菌,菌株菌,蛋白菌,拉克诺斯皮拉菌) 不会对基底细胞癌 (BCC) 的发病率产生遗传影响.
这些发现为肠道微生物群和BCC之间的关系提供了新的见解,表明这些特定微生物缺乏直接的遗传因果关系.

关键词:

基底细胞癌,基底细胞癌.有关因果关系的因果关系遗传学遗传学遗传学是一个我们的肠道微生物群.门德勒的随机化研究.

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