红细胞中的脂肪酸成分和冠状动脉疾病风险:中国的一项病例对照研究
Yongjin Wang1,2, Gangcheng Wu1, Feng Xiao2
1State Key Laboratory of Food Science and Resources, School of Food Science and Technology, International Joint Research Laboratory for Lipid Nutrition and Safety, National Engineering Research Center for Functional Food, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, Jiangnan University, Wuxi 214122, China. xingguow@jiangnan.edu.cn.
红细胞脂肪酸对中国成年人冠状动脉病 (CAD) 风险产生影响. 较高水平的omega-3多不和脂肪酸 (n-3PUFAs) 和单不和脂肪酸 (MUFAs) 有保护作用,而和脂肪酸 (SFAs) 和omega-6多不和脂肪酸 (n-6PUFAs) 增加风险.
科学领域:
- 营养流行病学 营养流行病学
- 心血管疾病研究研究
- 生物标志物发现发现
背景情况:
- 在红细胞脂肪酸和冠状动脉疾病 (CAD) 上存在相互矛盾的证据.
- 中国的高CAD流行率需要了解导致的因素.
- 红细胞脂肪酸成分可能会影响CAD易感性.
研究的目的:
- 调查红细胞脂肪酸成分与中国成年人CAD风险之间的关联.
- 为了确定与CAD发展相关的特定脂肪酸模式.
主要方法:
- 气相色谱用于测量314名CAD患者和314名对照者的红细胞脂肪酸.
- 多变量条件后勤回归和受限立方线模型分析了相关性.
- 主要成分分析 (PCA) 确定了红细胞脂肪酸模式 (FAPs).
主要成果:
- 红细胞总 n-3 多不和脂肪酸 (n-3 PUFA) 和单不和脂肪酸 (MUFA) 的增加与CAD风险呈反向关联.
- 和脂肪酸 (SFAs) 和n-6多不和脂肪酸 (n-6PUFAs) 的较高水平与CAD风险有关.
- 确定了四种不同的脂肪酸模式 (FAPs);FAP1和FAP2与增加的CAD风险相关,而FAP3和FAP4显示出一种保护性关联.
结论:
- 红细胞脂肪酸概况显著影响中国成年人CAD易感性.
- n-3 PUFA 和 MUFA 作为保护性生物标志物,而 SFAs 和 n-6 PUFA 与较高的 CAD 风险有关.
- 结合的红细胞脂肪酸模式可能比单个脂肪酸更为关键的CAD发展指标.
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