设施体积和改变设施,用于唾液腺癌的术后放射治疗
Rushi Patel1, Aman M Patel2, Lucy Revercomb2
1Department of Otolaryngology-Head and Neck Surgery, Cleveland Clinic College of Medicine, Cleveland, Ohio, U.S.A.
The Laryngoscope
|June 19, 2024
概括
在高容量设施 (HVF) 接受手术和术后放射治疗 (PORT) 的唾液腺癌 (SGC) 患者的生存率更好. 在HVF中更换PORT的设施显著恶化了SGC患者的生存结果.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 头部和部手术 头部和部手术
背景情况:
- 手术后放射治疗 (PORT) 位置影响头癌的存活率.
- 唾液腺癌 (SGC) 治疗涉及手术和经常PORT.
- 高容量设施 (HVF) 可能提供更优质的护理途径.
研究的目的:
- 调查PORT换衣设施与SGC患者的存活率之间的关联.
- 为了比较SGC患者在高体积与低体积设施治疗的结果.
- 确定PORT的设施变化是否可以独立预测SGC的存活率.
主要方法:
- 国家癌症数据库 (2004-2016) 对成年SGC患者进行手术和PORT治疗的分析.
- 根据年度病例负载,将设施分类为高容量 (> 95 个百分位数) 或低容量.
- 排除患有多种癌症,转移性疾病或未知PORT设施的患者.
主要成果:
- 在HVF治疗的患者患结节阳性和晚期T期疾病的比率更高.
- 在HVF治疗的SGC患者与LVF (79.0%对72.0%) 患者相比,显示出更好的5年整体存活率 (5-OS).
- 改变HVF的PORT设施与明显更差的5-OS (60.8%与83.2%) 有关,并且是低生存率的独立预测因素 (HR:8.99).
结论:
- 在HVF治疗的SGC患者,如果他们改变设施为PORT,他们的生存率会更差.
- 这些发现表明,在HVF接受手术的SGC患者应该在同一机构完成他们的PORT.
- 保持HVF的治疗连续性对于优化SGC的生存至关重要.
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