随着衰老发生改变的葡萄糖动力学:一种关于代谢灵活性的新观点
Casey C Curl1, Robert G Leija1, Jose A Arevalo1
1Exercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, California, United States.
老年人在口服葡萄糖耐受性测试 (OGTT) 中表现出抑制的葡萄糖动力学,这表明代谢灵活性降低. 呼吸交换比率 (RER) 测量不能完全捕捉这些与健康个体的年龄相关的变化.
科学领域:
- 老年学是一门学科.
- 代谢生理学 代谢生理学
- 营养科学 营养科学
背景情况:
- 代谢灵活性对于维持葡萄糖平衡至关重要.
- 衰老与代谢功能的改变有关,但它对健康个体的葡萄糖动力学和代谢灵活性的影响需要进一步阐明.
- 呼吸交换比率 (RER) 通常用于评估代谢灵活性,但其在不同年龄组的有效性尚未完全确立.
研究的目的:
- 研究年龄对健康的年轻人和老年人的代谢灵活性和葡萄糖动力学的影响.
- 在年轻人和老年人之间进行口服葡萄糖耐受性测试 (OGTT) 期间比较葡萄糖动力学和RER.
- 确定RER是否是衰老中代谢灵活性的可靠指标.
主要方法:
- 使用稳定同位素标记物 ([6,6-2H]葡萄糖和[3-13C]乳酸盐) 和肺气交换测量.
- 在过夜禁食后,进行了为期2小时的75克口服葡萄糖耐受性测试 (OGTT).
- 测量出现率 (Ra),处置率 (Rd),代谢清除率 (MCR) 和分数葡萄糖生成 (fGNG),以评估葡萄糖动力学.
主要成果:
- 葡萄糖动力学,包括Ra,Rd和MCR,与年轻人相比,在老年人中被显著抑制.
- 分数葡萄糖生成 (fGNG) 在葡萄糖挑战后的老年人中仍然较高,与年轻人不同.
- 在年轻人和老年人之间没有观察到禁食或峰值RER值的显著差异,这表明RER在这种情况下是代谢灵活性的不完整度量.
结论:
- 健康的衰老与口服葡萄糖挑战后抑制的葡萄糖动力学和改变的葡萄糖生成有关.
- 在OGTT期间的RER测量不能充分反映健康个体的葡萄糖代谢和代谢灵活性与年龄相关的变化.
- 需要进一步的研究,以确定可靠的生物标志物在老龄化人口的代谢灵活性.
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