估计的脉冲波速度与多民族多样化人口的认知功能的关联:北曼哈顿研究
Botagoz Aimagambetova1,2, Taylor Ariko1,3, Hannah Gardener1,2
1Evelyn F. McKnight Brain Institute, Miami, Florida, USA.
概括
通过估计脉冲波速度 (ePWV) 测量的动脉硬与老年人的认知能力下降有关. 较高的ePWV预测认知功能较差,衰退速度更快,突出显示血管健康.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 老年学是一门学科.
背景情况:
- 动脉硬是已知的与年龄相关的认知功能障碍的贡献者.
- 估计的脉冲波速度 (ePWV) 是与脑血管疾病相关的指标.
研究的目的:
- 调查ePWV与多民族人口的认知表现之间的关联.
- 为了确定ePWV是否会随着时间的推移预测认知能力下降.
主要方法:
- 来自北曼哈顿研究的1257名参与者在基线和随访 (平均5.0年后) 接受了认知评估.
- 使用基线年龄和血压计算ePWV.
- 多变量线性回归模型用于分析与ePWV相关的认知和认知变化.
主要成果:
- 经过调整后,较高的ePWV与较差的认知表现 (b = -0.100) 和较大的认知衰退 (b = -0.063) 有关.
- 在全球认知,处理速度,情节性记忆,执行功能和语义记忆中观察到关联.
- 通过种族和性别观察到效果的改变,在女性中,ePWV与情节性记忆衰退之间存在更强的关联.
结论:
- 在老年人中,ePWV是认知功能和认知功能下降的独立预测指标.
- 根据ePWV的指标,血管硬在与年龄相关的认知障碍中起着重要作用.
- 研究结果强调了血管健康在整个衰老过程中保持认知功能的重要性.
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