唐氏综合征和阻塞性睡眠呼吸暂停儿童的腺切除术结果:一个单中心研究
Egambaram Senthilvel1, Kahir Jawad2, Alessandra M Gearhart3
1Department of Pediatrics, University of Louisville and Norton Children Medical Group, 9880 Angies Way Suite 300, Louisville, KY, KY40241, USA. Egambaram.senthilvel@louisville.edu.
Sleep & breathing = Schlaf & Atmung
|June 19, 2024
概括
桃切除和腺切除 (T&A) 在患有唐氏综合征 (DS) 的儿童中显著改善了阻塞性睡眠呼吸暂停 (OSA),但残留中度至重度的OSA在一半以上的儿童中持续存在. 氧气脱度水平预测了T&A后持续的OSA.
科学领域:
- 儿科耳鼻喉科 儿科耳鼻喉科
- 睡眠医学 睡眠医学
- 遗传学 遗传学 是一个
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 在患有唐氏综合征 (DS) 的儿童中非常普遍.
- 桃腺切除术 (T&A) 是儿童OSA的常见治疗方法.
- 在患有DS和OSA的儿童中,T&A的有效性需要进一步评估.
研究的目的:
- 为了评估多睡眠图 (PSG) 结果后T&A在儿童与DS和OSA.
- 为了比较PSG与DS儿童和非DS儿童之间的T&A结果.
主要方法:
- 回顾性,单中心研究.
- 包括患有DS和OSA的儿童,他们接受了手术前和手术后PSG的T&A.
- 将PSG变量与年龄和性别匹配的非DS儿童组进行了比较.
主要成果:
- 在患有DS的儿童中,T&A显著降低了阻塞性呼吸暂停-呼吸暂停指数 (OAHI) 和非REM AHI (p<0.05).
- 然而,54.2%的DS儿童在T&A后仍然有中度至重度的OSA.
- 氧气不和极点预测残留中度至重度的OSA (p=0.002).
- 在DS和非DS组之间没有观察到明显的手术前和手术后的PSG差异.
结论:
- 在DS患有OSA的儿童中,T&A提供了显著的OAHI改善,但残留疾病很常见.
- 在这个人群中,氧气不和底是T&A后持续性OSA的关键预测因素.
- 与非DS同龄人相比,DS儿童在T&A后没有显著的PSG结果差异.
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