益生菌减少老年人的炎症:一个随机,双盲,安慰剂控制的试验
Irini Lazou-Ahrén1, Malin Björklund1, Göran Molin2
1Probi AB, Lund, Sweden.
在老年人中,益生菌摄入量适度降低了炎症标志物. Lactiplantibacillus plantarum HEAL9 (LpHEAL9). 虽然没有显著影响血清CRP,但LpHEAL9降低了便calprotectin,这表明对衰老健康的潜在益处.
科学领域:
- 老年学是一门学科.
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 人口老龄化面临着健康老龄化的挑战,原因是慢性低度炎症,称为"炎症".
- 了解缓解炎症的干预措施对于改善老年人的生活质量至关重要.
研究的目的:
- 调查 Lactiplantibacillus plantarum HEAL9 (LpHEAL9) 单独和果的抗炎作用,在患有慢性轻度炎症的老年人中.
- 评估LpHEAL9对炎症标志物和认知功能的影响.
主要方法:
- 一个随机,双盲,安慰剂控制的试验,涉及66名70岁以上的志愿者.
- 参与者被分配到安慰剂,LpHEAL9或LpHEAL9+果组进行为期4周的饮食干预.
- 关键的结果措施包括血清C反应蛋白 (CRP),便calprotectin和认知功能测试.
主要成果:
- LpHEAL9摄入量显示出降低血清CRP的趋势,但没有统计学意义.
- 与安慰剂相比,在LpHEAL9组观察到便calprotectin水平显著降低.
- LpHEAL9 + 果组合没有显示出显著的抗炎作用. 两组益生菌都显示了改善认知功能的非显著趋势.
结论:
- 益生菌菌株L. plantarum HEAL9在健康的老年人中对低度炎症产生了适度的影响.
- 在老年人中,LpHEAL9可能是管理肠道炎症的潜在辅助.
- 需要进一步的研究来探索 LpHEAL9 的协同效应和最佳剂量,以实现健康的衰老.
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