紫外线衰老的微塑料和细胞损伤:一个体外研究
Sebastiano La Maestra1, Mirko Benvenuti2, Stefano Alberti3
1Department of Health Sciences, University of Genoa, Via A. Pastore, 1, 16132, Genoa, Italy. Sebastiano.lamaestra@unige.it.
Archives of environmental contamination and toxicology
|June 19, 2024
概括
紫外线衰老的微塑料 (MP) 和更小的尺寸诱导了人类细胞的基因毒性损伤和氧化应激. 这凸显了环境塑料污染对健康的潜在风险.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 材料科学 材料科学 材料科学
背景情况:
- 塑料废物是一个全球性问题,通过各种降解过程将塑料碎片化为微塑料 (MP).
- 微塑料是普遍存在的环境污染物,通过包括人类在内的生物体的摄入和吸入,构成风险.
研究的目的:
- 调查原始和UV老化聚烯微塑料 (1和5微米) 对THP-1细胞系的基因毒性和氧化应激影响.
- 描述UVB暴露后的微塑料颗粒,以了解衰老效应.
主要方法:
- 福利埃变换红外光谱学和泽塔电位测量被用于微塑料的特征.
- 为了评估细胞损伤,THP-1单细胞细胞系暴露在聚烯微塑料中.
- 测量了反应性氧化物种 (ROS) 生产和甲水平,以评估氧化应激.
- 对基因毒性损害进行了评估,以确定微塑料暴露的影响.
主要成果:
- 紫外线暴露改变了微塑料的特性.
- 微塑料暴露导致反应性氧化物种 (ROS) 和甲水平增加,表明氧化应激.
- 观察到基因毒性损伤,特别是较小和紫外线老化的微塑料颗粒.
- 在暴露细胞中检测到生化和基因组变化.
结论:
- 紫外线老化和较小的微塑料在体外引起显著的基因毒性损伤和氧化应激.
- 这些发现表明,暴露于降解的微塑料的人群可能会对健康产生不良影响.
- 进一步的研究至关重要,以充分阐明与微塑料污染相关的健康风险.
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