绘制克罗恩氏病病源与Mycobacterium paratuberculosis的病源:一个隐形病原体的劫持
Gaurav Agrawal1,2, Thomas J Borody3, John M Aitken4
1Division of Diabetes & Nutritional Sciences, King's College London, Franklin-Wilkins Building, London, SE1 9NH, UK. Gaurav.agrawal@kcl.ac.uk.
这种细菌是Mycobacterium avium ssp. 甲状腺结核病 (MAP) 可以通过多步骤过程引起克罗恩病 (CD). 改进的检测方法对于确认这种传染性联系和指导组合疗法至关重要.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 这种细菌是Mycobacterium avium ssp. 帕拉结核病 (MAP) 是可疑导致克罗恩氏病 (CD) 的病因,与反动物的约翰氏病 (JD) 有病理相似之处.
- 据认为CD的发展涉及MAP感染,肠道失调和饮食因素,需要全面了解有效治疗.
研究的目的:
- 审查MAP在克罗恩氏病发病过程中的潜在作用.
- 探索MAP在牛和其他人类真菌细菌感染中已知的致病性如何为我们对CD的理解提供信息.
- 讨论在CD患者中对MAP的诊断测试的挑战和影响.
主要方法:
- 对MAP,JD,CD和真菌细菌感染的现有文献的综述.
- 分析JD和CD之间的病理和临床相似之处.
- 检查目前用于CD中MAP检测的诊断方法.
主要成果:
- 目前的诊断测试 (PCR,DNA测序,培养) 无法确定MAP和CD之间的确切联系.
- 显微镜和组织病理学提供了洞察到in situ菌根活动和疾病的表现,如颗粒瘤.
- 了解MAP在牛和其他人类真菌细菌感染中的致病性,为其在CD中的潜在作用提供了一个框架.
结论:
- 改进和准确的MAP检测方法对于确认CD的传染病因是必不可少的.
- 从人类肠道组织中分离,识别和培养MAP将加强因果关系证据.
- 将组合疗法 (抗生素,FMT,饮食) 定制为适应MAP活动,需要对其存在和影响提供强有力的微生物学证据.
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