心血管健康与肝硬化和死亡率之间的关联:来自综合横截面研究的见解
Ziqing Yu1, Xuemin Yan1, Xiaoyin Bai1
1Departments of Gastroenterology.
Journal of clinical gastroenterology
|June 19, 2024
概括
生命的基本8 (LE8) 心血管健康指标与肝硬化没有直接联系. 然而,改善的健康行为与降低肝硬化风险和降低患有肝硬化患者的死亡率有关.
科学领域:
- 心血管健康 心血管健康
- 肝脏疾病研究 肝脏疾病研究
- 公共卫生 公共卫生
背景情况:
- 肝硬化是一个日益增长的全球健康挑战,死亡率不断上升.
- 心血管健康 (CVH) 越来越多地被认为对肝病进展的潜在影响.
- 这项研究研究了与肝硬化有关的新生命的基本8 (LE8) 度量.
研究的目的:
- 检查生活必需品8 (LE8) 评分和肝硬化患病率之间的关联.
- 探索LE8成分与肝硬化风险之间的关系.
- 评估LE8对肝硬化患者全因死亡率的影响.
主要方法:
- 利用来自国家健康和营养检查调查 (2005-2018) 的数据,对20岁及以上的参与者进行了调查.
- 使用生命必需8 (LE8) 评分评估心血管健康,包括4种健康行为和4种健康因素.
- 根据肝功能测试 (AST/血小板比指数>2) 确定肝硬化,并通过国家死亡指数跟踪全因死亡率.
主要成果:
- 在生命的基本8 (LE8) 评分和肝硬化之间没有发现直接关联.
- 在LE8的健康行为组件中得分更高与肝硬化发病率较低有关.
- 在肝硬化患者的LE8分数和全因死亡率之间观察到一个反向的U形关系,在60分以上看到的好处.
- 改善健康行为显著降低了肝硬化患者全因死亡率的比例.
结论:
- 虽然LE8本身与肝硬化没有直接联系,但其健康行为组成部分与较低的肝硬化患病率有关.
- 优先考虑健康的生活方式选择,包括饮食,运动和戒烟,可能为肝硬化患者提供显著的好处.
- 通过既定行为改善心血管健康可能是治疗肝硬化及其并发症的关键策略.
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