Bifidobacterium infantis的肠道持久性是由宿主基因和抗生素暴露的相互作用决定的
Yiming Wang1,2, Jocelyn M Choo1,2, Alyson C Richard1,2
1Microbiome and Host Health Programme, South Australian Health and Medical Research Institute, Adelaide, South Australia 5001, Australia.
The ISME journal
|June 19, 2024
概括
一种常见的遗传变异影响益生菌的持久性. 这项研究表明,分泌者状态和抗生素的使用影响了Bifidobacterium infantis如何殖民肠道,解释了各种益生菌反应.
科学领域:
- 微生物学 微生物学
- 主体与微生物的相互作用
- 遗传学 是一个遗传学.
背景情况:
- 益生菌调节宿主-微生物相互作用,但显示效果不一致.
- 益生菌反应的个体间变异性是显著的.
- 一种常见的基因变异影响着基化甘氨酸可能解释了这些差异.
研究的目的:
- 为了研究一种遗传变异 (Fut2) 是否影响益生菌的持久性.
- 探索粘膜α(1,2) -fucosylated glycans在Bifidobacterium殖民中的作用.
- 了解基于宿主遗传学和抗生素暴露的益生菌反应的变异性.
主要方法:
- 使用一个小鼠模型 (Fut2WT和Fut2KO) 来研究Bifidobacterium菌株 (infantis, breve, bifidum).
- 分析了抗生素治疗后的肠道微生物群组成和益生菌移植.
- 在具有完整和破坏微生物群的小鼠中评估益生菌持久性.
主要成果:
- Fut2WT小鼠表现出基线丰富的微生物使用fucosylated glycans.
- 只有Fut2WT小鼠在抗生素移植后表现出持久的Bifidobacterium infantis.
- 在Fut2KO小鼠中,具有完整的微生物群的B. infantis持久性被逆转.
结论:
- 主体在分泌者状态 (Fut2) 中的遗传变异显著影响Bifidobacterium infantis的动态.
- 抗生素暴露调节了分泌者状态和益生菌持久性之间的关系.
- 这种相互作用可能解释了对诸如B. infantis.等益生菌的可变反应.
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