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身体组成表型的流行及其与血糖,脂质和炎症生物标志物的关联:基于人口的研究
Giovanna Mozzaquattro Nascimento1, Giana Zarbato Longo1, Aline Valmorbida1
1Universidade Federal de Santa Catarina, Florianópolis, Brasil.
这项研究发现,高葡萄糖和胆固醇等异常血液标志物与肥胖有关. 诸如hs-CRP和HOMA-IR之类的特定标志物也与形肥胖症有关,这表明它们在查中的使用.
科学领域:
- 内分泌学 在内分泌学.
- 老年学是一门学科.
- 营养科学 营养科学
背景情况:
- 身体构成表型,包括肥胖和皮症,越来越被认为是关键的健康指标.
- 了解代谢和炎症生物标志物与这些表型之间的关联对于公共卫生至关重要.
- 肥胖症 (SO) 是一种复杂的疾病,可能会对健康产生重大影响.
研究的目的:
- 在20-59岁的人群中确定肥胖,皮症和皮性肥胖的患病率.
- 调查血糖,脂质和炎症生物标志物与身体组成表型之间的关联.
- 为了确定肥胖和SO的潜在查标志物.
主要方法:
- 这是一项基于人口的横截面研究,涉及720名参与者 (年龄在20-59岁).
- 使用双能X射线吸收计评估的身体组成.
- 患病率计算为肥胖 (男性体脂率≥25%,女性体脂率≥32%),皮症 (尾肌肉质量指数<7.0kg/m2男性,<5.5kg/m2女性) 和SO.
- 用于分析生物标志物和表型之间的关联的多项逻辑回归模型,对混因素进行了调整.
主要成果:
- 患病率为:肥胖62.5%,肉症4.5%,SO6.2%. 这些都是患病率.
- 血糖增加,总胆固醇 (TC),LDL-c,VLDL-c,非HDL-c,甘油三 (Tg) 和降低的HDL-c与肥胖有关.
- 增加的HOMA-IR,LDL-c,非HDL-c和hs-CRP独立地与SO相关.
结论:
- 异常的血糖和脂质概况与肥胖表型有显著的关联.
- 升高的hs-CRP,HOMA-IR,LDL-c和非HDL-c水平与sarcopenic肥胖现象型有关.
- 这些生物标志物可能成为查肥胖和SO的宝贵附加工具.
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