在多发性硬化症中,大脑脊髓液的皮层和深灰质损伤的梯度
Martina Rubin1, Elisabetta Pagani1, Paolo Preziosa1
1From the Neuroimaging Research Unit (M.R., E.P., P.P., A.M., L.S., M.M., M.F., M.A.R.), Division of Neuroscience; Neurology Unit (M.R., P.P., M.M., M.F., M.A.R.), IRCCS San Raffaele Scientific Institute; Vita-Salute San Raffaele University (M.R., P.P., M.F., M.A.R.); Neurorehabilitation Unit (M.M., M.F.); and Neurophysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy.
Neurology(R) neuroimmunology & neuroinflammation
|June 19, 2024
概括
多发性硬化症 (MS) 患者在脑脊液 (CSF) 附近显示灰色物质损伤梯度. 这些模式因大脑区域和疾病过程而异,表明脱髓化和铁积累动态不同.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 放射学 放射学是一门学科.
背景情况:
- 多发性硬化症 (MS) 的特点是灰色质 (GM) 损伤,已知损伤梯度从脑脊液 (CSF) 延伸.
- 了解这种损伤的空间分布和微观结构基础对于评估疾病进展和开发向治疗至关重要.
研究的目的:
- 研究MS患者中与CSF不同距离的皮质,乳头和尾状基因组中微观结构异常的模式.
- 探索这些异常与临床和结构性MRI测量之间的关系.
主要方法:
- 一个使用3T 3D T1加权MRI扫描的横截面研究.
- 在25%-50%-75%深度的皮质层和从心室-GM接口的2-3-4个voxels的thalamic/caudate带采样.
- 使用线性混合模型分析磁化转移比率 (MTR) 和R2*值,将MS患者与对照组进行比较,并将研究结果与临床和结构性MRI数据相关联.
主要成果:
- 与对照组相比,患有复发性复发性多发性硬化症 (RRMS) 和进展性多发性硬化症 (PMS) 的患者在皮质和胸膜的GM中表现出较低的MTR和R2*值,图案因层而异.
- 产前综合征在尾状基因组中显示了额外的异常,包括更高的R2*值.
- 无论是RRMS还是PMS,MTR和R2*的损伤都显示出CSF-in梯度,PMS在某些地区显示出更明显的梯度. 这些损伤梯度与疾病持续时间,残疾,病变负载和大脑体积相关.
结论:
- 转基因中CSF损伤梯度在不同大脑区域和MS疾病过程中异质.
- 这些发现表明,不同的病理生理过程,包括脱髓化和铁积累/损失,有助于MS的转基因损伤.
- 观察到的梯度及其相关性突出显示了MS神经退行症的复杂性及其对大脑结构的影响.
相关概念视频
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CSF Production
CSF is produced mainly in the choroid plexus, a network of capillaries and ependymal cells located within the ventricular system of the brain.
CSF Production
CSF is produced mainly in the choroid plexus, a network of capillaries and ependymal cells located within the ventricular system of the brain.
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