美国成年人暴露于有机农药和自杀念头之间的关联:基于人口的研究
Mo-Yao Tan1, Shan Wu2, Si-Xuan Zhu2
1Chengdu Integrated TCM and Western Medicine Hospital, Chengdu, Sichuan, China.
Ecotoxicology and environmental safety
|June 19, 2024
概括
暴露于有机农药 (OPP),特别是二甲基硫酸 (DMTP),与成人自杀念头 (SI) 的增加有关. 年轻和老年男性对这些农药效应的敏感性增加.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 有机农药 (OPPs) 广泛使用,引发了对潜在神经毒性影响的担忧.
- 自杀念头 (SI) 是一个重要的公共卫生问题,具有多因素的原因.
- 了解SI的环境风险因素对于预防策略至关重要.
研究的目的:
- 调查成年人暴露于有机农药 (OPP) 和自杀念头 (SI) 之间的关联.
- 确定特定的OPP代谢物和最容易受到这些影响的人口子组.
- 评估多个OPP风险对SI的累积影响和相互作用.
主要方法:
- 利用了来自全国健康和营养检查调查 (NHANES) 的四个周期的数据,其中包括5244名成年参与者.
- 使用患者健康问卷-9评估SI并测量尿样中的OPP代谢物水平.
- 采用多变量逻辑回归,WQS回归和BKMR模型进行关联和累积影响分析,包括按人口统计和健康状况进行分层分析.
主要成果:
- 甲基二甲基酸盐 (DMTP) 显示出与SI (OR:1.18) 的统计学上显著的正相关性.
- WQS和BKMR模型证实了混合OPP代谢物和SI之间的显著关联,DMTP是主要的贡献者.
- 分层分析显示,OPP对年轻和老年男性的SI有明显的影响.
结论:
- 暴露于DMTP与自杀念头 (SI) 的风险增加有关.
- 年轻的成年男性和老年男性特别容易受到OPP暴露的不良心理健康影响.
- 这些发现凸显了对环境毒素作为潜在导致自杀意念的潜在因素的进一步研究的需要.
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