在自闭症谱系障碍中,后带带皮层的功能连接性
Myriam Kornisch1, Claudia Gonzalez2, Toshikazu Ikuta2
1Department of Communication Sciences & Disorders, University of Mississippi, Oxford, MS, USA; Department of Communication Sciences & Disorders, University of Maine, Orono, ME, USA.
Psychiatry research. Neuroimaging
|June 19, 2024
概括
自闭症谱系障碍 (ASD) 显示了大脑连接的改变. 患有自闭症的青少年在后 cingulate 皮质和前 cingulate 皮质之间表现出功能连接性减少,这可能表明重复性行为的一个生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 临床神经科学 临床神经科学
背景情况:
- 自闭症谱系障碍 (ASD) 是一种复杂的神经发育状况.
- 重复和限制行为 (RRBs) 是ASD的一个核心症状.
- 后带带皮层 (PCC) 和前带带皮层 (ACC) 参与与ASD相关的认知和行为功能.
研究的目的:
- 在患有自闭症谱系障碍 (ASD) 的青少年中研究后带带皮层 (PCC) 的功能连接性.
- 探索PCC功能连接和ASD核心症状,特别是RRBs之间的关系.
主要方法:
- 利用自闭症脑成像数据交换 (ABIDE) 联盟的静止状态功能磁共振成像 (rsfMRI) 数据.
- 分析了来自两个网站的数据:密歇根大学 (145名受试者) 和纽约大学 (183名受试者).
- 在被诊断为ASD的青少年和神经类型对照组之间比较功能连接模式.
主要成果:
- 与对照人群相比,患有自闭症的青少年在后带状皮质 (PCC) 和前带状皮质 (ACC) 之间的功能连接显著减少.
- 这些特定的PCC-ACC连接性改变与ASD组的重复性和限制性行为 (RRB) 的严重程度有关.
- 这些发现表明,与PCC和ACC功能障碍相关的ASD中RRB的神经生物学基础.
结论:
- 该研究确定了PCC和ACC之间的功能连接的改变是自闭症谱系障碍潜在的神经生物学标志物.
- 这些连接性变化可能是ASD个体中观察到的重复性和受限制行为的表达的基础.
- 对PCC-ACC连接的进一步研究可以为ASD的诊断和治疗策略提供信息.
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