在下体负压期间进行皮肤过渡的阴道神经刺激
Johan Casper Grove Petersen1, Rachel Becker2, Lonnie G Petersen3
1Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Cambridge, MA, USA.
Autonomic neuroscience : basic & clinical
|June 19, 2024
概括
通过皮肤进行的阴道神经刺激 (tVNS) 并没有完全阻断对血液体积减少的同情反应. 然而,tVNS选择性地降低了心率,这表明潜在的心脏抑制作用.
科学领域:
- 心血管生理学心血管生理学
- 自主神经系统调节自主神经系统调节
- 神经调节是一种神经调节.
背景情况:
- 副交感神经系统通过阴道激活显著影响心率和心血管功能.
- 通过皮肤进行的阴道神经刺激 (tVNS) 针对的是阴道神经的耳部分支.
研究的目的:
- 调查tVNS是否可以减弱对由下体负压 (LBNP) 诱导的中枢血液体积减少的同情反应.
主要方法:
- 一项涉及10名健康志愿者的交叉试验,这些志愿者在15分钟的时间内接受了30 mmHg的LBNP.
- 干预期包括周期性tVNS和无刺激.
- 使用Nexfin.使用连续监测心血管参数.
主要成果:
- 总的来说,tVNS没有令人信服地减弱对低血压的同情反应.
- 在LBNP期间tVNS的失活导致了平均动脉压 (MAP) 的显著增加.
- 与暂停期间相比,活跃的tVNS刺激期显示心率 (HR) 降低,并随之增加中风体积 (SV),MAP和总外周阻力 (TPR).
结论:
- 在LBNP期间用30秒周期的tVNS可以选择性地减弱心率.
- 这种减弱可能会促使同情反应的补偿性增加.
- 这项研究表明tVNS具有孤立的心脏抑制作用,可能是通过心脏节点上增强的阴道活动和减少交感心脏神经活动.
相关概念视频
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