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Updated: Jun 23, 2025

High-Throughput Optical Controlling and Recording Calcium Signal in iPSC-Derived Cardiomyocytes for Toxicity Testing and Phenotypic Drug Screening
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High-Throughput Optical Controlling and Recording Calcium Signal in iPSC-Derived Cardiomyocytes for Toxicity Testing and Phenotypic Drug Screening

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一个诱导的多能干细胞系,携带一种耐沉默的记者等位基因

Madel Durens1, Erdene Baljinnyam2, Laura Grisanti2

  • 1Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Institute for Regenerative Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Stem cell research
|June 19, 2024
PubMed
概括

我们开发了一种新的人类诱导多能干细胞 (iPSC) 系列,用于在神经元中强大的成像. 这条线确保了传感器 (GCaMP6) 的稳定表达,克服了转基因沉默问题.

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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