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Updated: May 12, 2026

Metabolic Mapping: Quantitative Enzyme Cytochemistry and Histochemistry to Determine the Activity of Dehydrogenases in Cells and Tissues
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Published on: May 26, 2018

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发现新型自然产品衍生突变异酸脱酶1抑制剂:基于结构的虚拟查,生物评估和结构-活性关系研究

Tieling Xu1, Junya Yang1, Dongsheng Li1

  • 1Department of Medicinal Chemistry, School of Pharmacy, Chongqing Medical University, Chongqing, 400016, PR China.

European journal of medicinal chemistry
|June 19, 2024
PubMed
概括

研究人员发现了一种新化合物,11s,它有效地抑制异酸脱酶1 (IDH1) 突变. 在临床前模型中,这种化合物降低了促进瘤的2-基酸盐 (2-HG) 水平,并抑制了癌细胞的增殖和生长.

关键词:
这是一种抗癌药物.癌症代谢 癌症代谢异酸脱酶 1 异酸脱酶 1基于结构的虚拟选.

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