21世纪在英国和主要西方国家加速神经死亡: - 人口和/或多重交互环境原因?
Colin Pritchard1, Anne Silk1, Lars Hansen1
1Southampton University, UK.
Journal of the neurological sciences
|June 19, 2024
概括
神经死亡率正在显著上升,这不仅仅是由于人口老龄化. 这表明神经系统疾病的增加需要对环境,生活方式和卫生系统因素进行紧急调查.
科学领域:
- 神经学 神经学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 神经死亡率在21世纪显著增加.
- 戈珀茨假说将死亡率与衰老联系起来,已被提出作为一个解释.
- 然而,最近的数据表明,这种假设可能不能完全解释观察到的趋势.
研究的目的:
- 调查21世纪神经死亡率的上升情况.
- 确定戈珀茨假设是否足够解释这些增加.
- 探索观察到的死亡率趋势的潜在替代解释.
主要方法:
- 分析了两个大型数据集:英格兰/威尔士国家统计局 (ONS) 和世界卫生组织 (WHO) 的全球死亡率数据.
- 对2000-2022年 (ONS) 和2000-2015年 (WHO) 的综合神经死亡率 (CNM) 的年龄标准化死亡率 (ASMR) 的检查.
- 包括特定的神经疾病,如阿尔茨海默氏症,痴呆症和帕金森病,以及分析十个主要西方经济体中成年人早期死亡率 (55-74岁).
主要成果:
- 在英格兰和威尔士,阿尔茨海默病的死亡率增加了348%,痴呆症增加了235%,帕金森病增加了105%.
- 在早期成年人 (55-74岁) 中,综合神经死亡率 (CNM) 在八个西方国家平均上升了19%.
- 神经性ASMR在所有10个研究国家都增加了,平均为43%,英国的增加率最高,为95%.
结论:
- 戈珀茨假设不足以作为观察到的神经死亡率增加的唯一解释.
- 成人早期神经死亡率的上升表明,除了人口老龄化之外的因素也在发挥作用.
- 建议对环境,生活方式和卫生系统因素进行紧急调查,以了解和解决不断增加的神经死亡率的问题.
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