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在Ilex pubescens的根部中具有生物活性的化学成分

Zihao Tan¹, Yongkang Li¹, Yuhong Wu¹

¹Guangdong Provincial Key Laboratory of Translational Cancer Research of Chinese Medicines, Joint International Research Laboratory of Translational Cancer Research of Chinese Medicines, International Institute for Translational Chinese Medicine, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China.

|June 19, 2024

概括

这项研究从Ilex pubescens根中分离了五种新化合物,揭示了显著的抗炎和心脏保护作用. 化合物1,4和8显示出强大的抗炎活性,而其他化合物在细胞模型中显示出显著的心脏保护作用.

科学领域:

自然产品化学自然产品化学
药理学药理学是指药理学的学科.

背景情况:

伊力克斯青春期的根是一种生物活性化合物的来源.
了解化学成分及其生物活性对于潜在的治疗应用至关重要.

研究的目的:

从Ilex pubescens根中分离和描述新的化合物.
评估隔离化合物的抗炎和心脏保护作用.

主要方法:

使用综合光谱技术 (IR,UV,HR-ESI-MS,NMR) 来隔离化合物.
在脂聚糖 (LPS) 诱导的RAW264.7细胞中对抗炎症活性的评估.
在氧气-葡萄糖剥夺/再输液 (OGD/R) 诱导的H9c2细胞中对心脏保护作用的评估.

主要成果:

确定了两种新的三类化合物 (ilexsaponin U,V) 和三种新的类化合物 (pubescenoside S,T,U),以及34种已知的化合物.
化合物1,4和8显著抑制了LPS诱导细胞中的炎症因子 (iNOS,IL-6,IL-1β,TNFα).
化合物2,3,7,8,26,35,36和37在OGD/R诱导的细胞中表现出显著的心脏保护作用,其中一些超过了阳性对照.

结论:

伊莱克斯 pubescens 根含有新的生物活性三烯酸和烯酸.
几个分离的化合物具有显著的抗炎和心脏保护性质,需要进一步研究药物开发.

关键词:

抗炎性活动抗炎性活动心脏保护作用 (OGD/R) 在体外.化学元件化学元件化学元件伊莱克斯 pubescensens 的时间.

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