创伤后幸存者的内与白质微观结构的改变有关
Philine Rojczyk1, Johanna Seitz-Holland2, Carina Heller3
1Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; cBRAIN, Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, Ludwig-Maximilians-University, Munich, Germany.
Journal of affective disorders
|June 19, 2024
概括
在患有PTSD的男性退伍军人中,幸存者的内与白质完整性降低有关. 这与对委托/遗漏的内形成鲜明对比,这表明幸存者内可能需要针对性脑健康干预.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 军人卫生保健 军人卫生保健
背景情况:
- 创伤后应激障碍 (PTSD) 在退伍军人中很普遍.
- 创伤后的内,包括对委托/遗漏和幸存者的内的内,是常见的症状.
- 幸存者内涉及强烈的痛苦,因为在其他人没有幸存时幸存下来.
研究的目的:
- 根据内类型,调查患有PTSD的男性退伍军人的神经解剖学差异.
- 为了比较白质微观结构,皮质厚度和内组之间的体积.
主要方法:
- 分析了132名患有PTSD的男性退伍军人的MRI数据.
- 使用CAPS-IV.将内分类为犯罪/遗漏,幸存者内或没有内.
- 在不同组中比较分数异构性 (FA),皮质厚度和体积.
主要成果:
- 与那些没有内的退伍军人相比,幸存者内的退伍军人在主要纤维捆绑中表现出明显较低的白质FA.
- 没有发现白质FA,皮质厚度或体积的显著差异,在那些对委托/遗漏感到内的退伍军人和那些没有内的退伍军人之间.
结论:
- 幸存者内与PTSD退伍军人的明显白质变化有关.
- 这些发现表明,幸存者内可能需要专注于大脑健康的特定治疗方法.
- 限制包括一个横截面设计和一个专门的男性样本,排除因果推理和概括性.
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