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在伊朗的希拉兹,B型流感病毒的HA抗原变异和家族遗传分析

Hajar Dastyar¹, Fahime Edalat², Neda Pirbonyeh³

¹Department of Bacteriology & Virology, Shiraz Medical School, Shiraz University of medical Sciences, Shiraz, Iran.

|June 19, 2024

概括

在伊朗的希拉兹市进行的B型流感病毒监测发现,亚马加塔族的血统占主导地位. 这凸显了对区域疫苗战略的需要,以对抗B型流感,一个重要的呼吸道疾病.

科学领域:

病毒学病毒学
流行病学流行病学
公共卫生公共卫生

背景情况:

流感B型病毒是导致呼吸系统疾病的重要原因,在全球范围内传播,其中包括维多利亚和山口流感.
流通的B型流感病毒和疫苗之间的菌株不匹配增加了死亡率和经济负担.
了解B型流感的流行病学和遗传学对于有效控制至关重要.

研究的目的:

为了研究B型流感病毒的遗传特征和流行病学,在伊朗的希拉兹.
分析流传的B型流感菌株的遗传关系.
为区域B型流感的预防和控制策略提供信息.

主要方法:

收集了235名患有流感症状的儿童的喉抽样,在伊朗的希拉兹 (2017年10月至2018年1月).
提取病毒RNA并进行实时PCR检测B型流感.
测序了血凝素 (HA) 基因,构建了家族遗传树,并确定了适应性突变.

主要成果:

在9.7%的样本中检测到B型流感病毒 (23/235).
鼻和肌痛是感染个体 (87%) 中最常见的症状.
遗传学分析揭示了与B/Phuket/3037/2013密切相关的Yamagata血统 (clade-3) 和与B/Brisbane/60/2008相关的维多利亚血统 (clade-1A) 菌株的主导性.

结论:

在希拉兹流传的B型流感菌株与推的山口疫苗菌株相匹配.
强调需要加强疫苗覆盖率和对HA基因突变的持续监测.
强调了针对B型流感的预防和控制区域具体战略的重要性.

关键词:

抗原变异的变化血凝素是血液中的一个组成部分.在B型流感疫情中,人类遗传学分析

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